{PDOC51017} {PS51017; CCT} {BEGIN} ********************** * CCT domain profile * ********************** The CCT (CONSTANS, CO-like, and TOC1) domain is a highly conserved basic module of ~43 amino acids, which is found near the C-terminus of plant proteins often involved in light signal transduction. The CCT domain is found in association with other domains, such as the B-box zinc finger (see ), the GATA-type zinc finger (see ), the ZIM motif or the response regulatory domain (see ). The CCT domain has been shown to be involved in nuclear localization and probably also has a role in protein-protein interaction [1,2]. Some proteins known to contain a CCT domain are listed below: - Plant CONSTANS family of transcription factors. - Plant GATA factor subfamily III [3]. - Arabidopsis thaliana timing of CAB expression 1 (TOC1) or ABI3-interacting protein 1 (AIP1). - Arabidopsis thaliana TOC1-Like (TL). The profile we developed covers the entire CCT domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: September 2004 / First entry. [ 1] Strayer C., Oyama T., Schultz T.F., Raman R., Somers D.E., Mas P., Panda S., Kreps J.A., Kay S.A. "Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog." Science 289:768-771(2000). PubMed=10926537 [ 2] Robson F., Costa M.M.R., Hepworth S.R., Vizir I., Pineiro M., Reeves P.H., Putterill J., Coupland G. "Functional importance of conserved domains in the flowering-time gene CONSTANS demonstrated by analysis of mutant alleles and transgenic plants." Plant J. 28:619-631(2001). PubMed=11851908 [ 3] Reyes J.C., Muro-Pastor M.I., Florencio F.J. "The GATA family of transcription factors in Arabidopsis and rice." Plant Physiol. 134:1718-1732(2004). PubMed=15084732; DOI=10.1104/pp.103.037788 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}