{PDOC51020}
{PS51020; SPONDIN}
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* Spondin domain profile *
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The spondin  domain  is  a  ~200  amino  acid  module containing two conserved
motifs, FS1  and  FS2,  that  is  shared by the vertebrate and invertebrate F-
spondin family of proteins, which includes both F-spondin and M-spondin/Mindin
(renamed Spon1  and  Spon2  respectively).  The  spondin  domain  is  found in
association with  other  modules,  such  as  the  thrombospondin type I repeat
(TSP1) (see <PDOC50092>), the reelin domain (see <PDOC51019>), the fibronectin
type III  domain  (see  <PDOC50853>)  or the Kunitz trypsin protease inhibitor
domain (see  <PDOC00252>). The function of the spondin domain is not known but
it might interact with other factors [1,2,3].

The profile we developed covers the entire spondin domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: September 2004 / First entry.

[ 1] Higashijima S., Nose A., Eguchi G., Hotta Y., Okamoto H.
     "Mindin/F-spondin family: novel ECM proteins expressed in the
     zebrafish embryonic axis."
     Dev. Biol. 192:211-227(1997).
     PubMed=9441663
[ 2] Feinstein Y., Borrell V., Garcia C., Burstyn-Cohen T., Tzarfaty V.,
     Frumkin A., Nose A., Okamoto H., Higashijima S., Soriano E., Klar A.
     "F-spondin and mindin: two structurally and functionally related genes
     expressed in the hippocampus that promote outgrowth of embryonic
     hippocampal neurons."
     Development 126:3637-3648(1999).
     PubMed=10409509
[ 3] Feinstein Y., Klar A.
     "The neuronal class 2 TSR proteins F-spondin and Mindin: a small
     family with divergent biological activities."
     Int. J. Biochem. Cell Biol. 36:975-980(2004).
     PubMed=15094111; DOI=10.1016/j.biocel.2004.01.002

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