{PDOC51036}
{PS51036; ZF_A20}
{BEGIN}
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* Zinc finger A20-type profile *
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NF-kappaB  transcription  factors  mediate  the  effects  of  pro-inflammatory
cytokines  such  as  TNF-alpha and interleukin-1 beta. Failure to downregulate
NF-kappaB  transcriptional  activity  results in chronic inflammation and cell
death  [1].  It  has  been  shown that A20 protein can downregulates NF-kappaB
signaling  by  targeting  receptor  interacting  protein  (RIP),  an essential
mediator  of  the  proximal  TNF receptor 1 (TNFR1) signalling complex, to the
proteasome [2].

The C-terminal  region of A20, is composed of seven C4-type zinc fingers, that
function  as a  ubiquitin  ligase by polyubiquitinating RIP with Lys-48-linked
ubiquitin chains, thereby targeting RIP for proteasomal degradation [2].

A20-type  zinc  fingers  are  found  in all eukaryotes and form fusions with a
variety of domains involved in ubiquitin signaling pathways.

The profile we developed covers the whole A20-type zinc finger.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: November 2004 / First entry.

[ 1] Dixit V., Mak T.W.
     "NF-kappaB signaling. Many roads lead to madrid."
     Cell 111:615-619(2002).
     PubMed=12464174
[ 2] Wertz I.E., O'Rourke K.M., Zhou H., Eby M., Aravind L., Seshagiri S.,
     Wu P., Wiesmann C., Baker R., Boone D.L., Ma A., Koonin E.V.,
     Dixit V.M.
     "De-ubiquitination and ubiquitin ligase domains of A20 downregulate
     NF-kappaB signalling."
     Nature 430:694-699(2004).
     PubMed=15258597; DOI=10.1038/nature02794

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