{PDOC51039} {PS51039; ZF_AN1} {BEGIN} ******************************** * Zinc finger AN1-type profile * ******************************** This domain was first identified as a putative zinc finger found in the protein encoded by the Xenopus laevis An1 maternal mRNA [1]. The AN1-type zinc finger contains six conserved cysteines and two histidines that could potentially coordinate 2 zinc atoms. The AN1-type zinc finger is frequently found associated with domains linked to the ubiquitination pathway, such as the A20-type zinc finger (see ), the ubiquitin-like domain (see ), or the UIM domain (see ). The function of the AN1-type zinc finger is not yet known. Some proteins known to contain an AN1-type zinc finger are listed below: - Ascidian posterior end mark 6 (pem-6) protein. Its mRNA is maternally expressed and localized in the posterior-vegetal cytoplasm of ascidian embryo [2]. - Human AWP1 protein (associated with PRK1). Its gene is turned on early during embryogenesis and ubiquitously expressed [3]. - Human immunoglobulin mu binding protein 2 (SMUBP-2). Mutations in the gene encoding SMUBP-2 cause spinal muscular atrophy with respiratory distress type 1 [4]. The profile we developed covers the whole AN1-type zinc finger. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: March 2021 / Profile revised. [ 1] Linnen J.M., Bailey C.P., Weeks D.L. "Two related localized mRNAs from Xenopus laevis encode ubiquitin-like fusion proteins." Gene 128:181-188(1993). PubMed=8390387 [ 2] Satou Y., Satoh N. "Posterior end mark 2 (pem-2), pem-4, pem-5, and pem-6: maternal genes with localized mRNA in the ascidian embryo." Dev. Biol. 192:467-481(1997). PubMed=9441682; DOI=10.1006/dbio.1997.8730 [ 3] Duan W., Sun B., Li T.W., Tan B.J., Lee M.K., Teo T.S. "Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo." Gene 256:113-121(2000). PubMed=11054541 [ 4] Grohmann K., Schuelke M., Diers A., Hoffmann K., Lucke B., Adams C., Bertini E., Leonhardt-Horti H., Muntoni F., Ouvrier R., Pfeufer A., Rossi R., Van Maldergem L., Wilmshurst J.M., Wienker T.F., Sendtner M., Rudnik-Schoneborn S., Zerres K., Hubner C. "Mutations in the gene encoding immunoglobulin mu-binding protein 2 cause spinal muscular atrophy with respiratory distress type 1." Nat. Genet. 29:75-77(2001). PubMed=11528396; DOI=10.1038/ng703 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}