{PDOC51049}
{PS51049; KASH}
{BEGIN}
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* KASH domain profile *
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The KASH  (for  Klarsicht/ANC-1/Syne-1  homology)  or  KLS  domain is a highly
hydrophobic nuclear envelope localization domain of ~60 amino acids comprising
an ~20-amino-acid  transmembrane  region and a 30-35-residue C-terminal region
that lies  between  the inner and the outer nuclear membranes. The KASH domain
is found  in  association  with other domains, such as spectrin repeats and CH
(see <PDOC50021>),  at  the  C-terminus  of  proteins  tethered to the nuclear
membrane in diverse cell types [1,2,3,4,5].

Some proteins known to contain a KASH domain are listed below:

 - Caenorhabditis elegans nuclear anchorage protein 1 (ANC-1).
 - Drosophila  Klarsicht (Klar), a protein associated with nuclei and required
   for a subset of nuclear migrations.
 - Drosophila MSP-300.
 - Vetebrate  nesprin-1  and  -2  (also  known  as  Syne-1  and  -2). They are
   associated with  emerin and lamin A at the nuclear envelope of muscle cells
   and other cell types.

The profile we developed covers the entire KASH domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / First entry.

[ 1] Mosley-Bishop K.L., Li Q., Patterson L., Fischer J.A.
     Curr. Biol. 9:1211-1220(1999).
[ 2] Apel E.D., Lewis R.M., Grady R.M., Sanes J.R.
     "Syne-1, a dystrophin- and Klarsicht-related protein associated with
     synaptic nuclei at the neuromuscular junction."
     J. Biol. Chem. 275:31986-31995(2000).
     PubMed=10878022; DOI=10.1074/jbc.M004775200
[ 3] Starr D.A., Han M.
     "Role of ANC-1 in tethering nuclei to the actin cytoskeleton."
     Science 298:406-409(2002).
     PubMed=12169658; DOI=10.1126/science.1075119
[ 4] Zhang Q., Ragnauth C., Greener M.J., Shanahan C.M., Roberts R.G.
     "The nesprins are giant actin-binding proteins, orthologous to
     Drosophila melanogaster muscle protein MSP-300."
     Genomics 80:473-481(2002).
     PubMed=12408964
[ 5] Fischer J.A., Acosta S., Kenny A., Cater C., Robinson C., Hook J.
     "Drosophila klarsicht has distinct subcellular localization domains
     for nuclear envelope and microtubule localization in the eye."
     Genetics 168:1385-1393(2004).
     PubMed=15579692; DOI=10.1534/genetics.104.028662

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