{PDOC51050} {PS51050; ZF_CW} {BEGIN} ******************************* * Zinc finger CW-type profile * ******************************* The CW domain is composed of four conserved cysteines and two tryptophan residues. The four cysteines could coordinate one zinc atom to form a new type of zinc finger. It is found exclusively in vertebrate, vertebrate-infected parasites and higher plants. The function of this zinc finger is not yet known but its taxonomic distribution and its association with a variety of domains involved in DNA binding, methylation, chromatin structure or ubiquitination suggest a putative role in epigenetic mechanisms and embryonic development [1]. The profile we developed covers the whole CW-type zinc finger. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: December 2004 / First entry. [ 1] Perry J., Zhao Y. "The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants." Trends Biochem. Sci. 28:576-580(2003). PubMed=14607086 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}