{PDOC51069}
{PS51069; GBP}
{BEGIN}
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* GBP repeat profile *
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Interactions between  Plasmodium falciparum merozoite and erythrocyte proteins
are essential  for  the  parasite's  survival.  One of the erythrocyte binding
proteins is  the  gylcophorin  binding  protein  (GBP-130),  which contains 11
highly conserved  50-residue-long  repeats. The GBP repeats have been shown to
bind to  the  erythrocyte  receptor  glycophorin. It appears that a minimum of
between 3.5  and  4.5  repeats  is  required  for  the  protein to bind to the
glycophorin matrix.  A  correlation  between  glycophorin  binding  and repeat
number might exist. GBPH is a Plasmodium protein highly homologous to GBP-130.
It carries  only  8 repeats of 40 residues, which can be superimposed on amino
acids 2-41 of the GBP repeats [1,2,3].

The profile we developed covers the entire GBP repeat.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: January 2005 / First entry.

[ 1] Kochan J., Perkins M., Ravetch J.V.
     "A tandemly repeated sequence determines the binding domain for an
     erythrocyte receptor binding protein of P. falciparum."
     Cell 44:689-696(1986).
     PubMed=3512098
[ 2] Nolte D., Hundt E., Langsley G., Knapp B.
     "A Plasmodium falciparum blood stage antigen highly homologous to the
     glycophorin binding protein GBP."
     Mol. Biochem. Parasitol. 49:253-264(1991).
     PubMed=1775169
[ 3] Suarez J.E., Urquiza M., Curtidor H., Rodriguez L.E., Ocampo M.,
     Torres E., Guzman F., Patarroyo M.E.
     "A GBP 130 derived peptide from Plasmodium falciparum binds to human
     erythrocytes and inhibits merozoite invasion in vitro."
     Mem. Inst. Oswaldo Cruz 95:495-501(2000).
     PubMed=10904405

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