{PDOC51071}
{PS51071; HTH_RPIR}
{BEGIN}
********************************
* RpiR-type HTH domain profile *
********************************

The  rpiR-type  HTH  domain is a DNA-binding, helix-turn-helix (HTH) domain of
about  75-80  amino  acids present in prokaryotic regulators of transcription.
The  domain  is  named  after  Escherichia  coli  rpiR,  also known as alsR, a
repressor  of the rpiB gene and the als operon, which encode proteins involved
in  sugar  metabolism.  The DNA-binding rpiR-type HTH domain occurs usually in
the  N-terminal  part;  the C-terminal part can contain a phosphosugar-binding
SIS  domain. Most rpiR-type HTH regulators are involved in sugar metabolism as
transcription repressors, but some are activators [1,2,3].

Some proteins known to contain a rpiR-type HTH domain:

 - Escherichia   coli   rpiR,   a   transcription   repressor   of   ripB,   a
   ribose-phosphate  isomerase,  and  of the als operon, involved in transport
   and metabolism of allose.
 - Pseudomonas  aeruginosa hexR, a transcription repressor of the hex regulon,
   involved in sugar metabolism.
 - Bacillus  subtilis  glvR,  a  transcription  activator  of  the glv operon,
   involved in transport and metabolism of maltose [3].

The profile we developed spans the entire rpiR-type HTH DNA-binding domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: January 2005 / First entry.

[ 1] Sorensen K.I., Hove-Jensen B.
     "Ribose catabolism of Escherichia coli: characterization of the rpiB
     gene encoding ribose phosphate isomerase B and of the rpiR gene, which
     is involved in regulation of rpiB expression."
     J. Bacteriol. 178:1003-1011(1996).
     PubMed=8576032
[ 2] Kim C., Song S., Park C.
     "The D-allose operon of Escherichia coli K-12."
     J. Bacteriol. 179:7631-7637(1997).
     PubMed=9401019
[ 3] Yamamoto H., Serizawa M., Thompson J., Sekiguchi J.
     "Regulation of the glv operon in Bacillus subtilis: YfiA (GlvR) is a
     positive regulator of the operon that is repressed through CcpA and
     cre."
     J. Bacteriol. 183:5110-5121(2001).
     PubMed=11489864

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}