{PDOC51073}
{PS51073; RPEL}
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* RPEL repeat profile *
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RPEL repeat  (RPxxxEL)  containing  proteins  are  found  in  a  wide range of
metazoan organisms.   RPEL   repeats  have  been  shown  to  be  required  for
unpolymerized actin  binding  and proteins containing RPEL repeats are able to
modify cell shape and/or are important in the regulation of gene expression by
the actin  cytoskeleton. RPEL repeats can be found in association with the SAP
motif (see <PDOC50800>), which could be involved in DNA binding [1,2].

Some proteins known to contain RPEL repeats are listed below:

 - Mammalian   myocardin,  heart-specific  serum  response  factor  (SRF)  co-
   activator.
 - Vertebrate  myocardin-related  transcription  factor  A  (MRTF-A or MAL), a
   signal-regulated SRF co-activator.
 - Vertebrate myocardin-related transcription factor B (MRTF-B).
 - Mammalian phosphatase and actin regulator 1 to 3.

The profile we developed covers the entire RPEL repeat.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: January 2005 / First entry.

[ 1] Miralles F., Posern G., Zaromytidou A.-I., Treisman R.
     "Actin dynamics control SRF activity by regulation of its coactivator
     MAL."
     Cell 113:329-342(2003).
     PubMed=12732141
[ 2] Favot L., Gillingwater M., Scott C., Kemp P.R.
     "Overexpression of a family of RPEL proteins modifies cell shape."
     FEBS Lett. 579:100-104(2005).
     PubMed=15620697; DOI=10.1016/j.febslet.2004.11.054

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