{PDOC51119}
{PS51119; TAFH}
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* TAFH/NHR1 domain profile *
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The  TAF  homology (TAFH) or Nervy homology region 1 (NHR1) domain is a domain
of 95-100 amino acids present in eukaryotic proteins of the MTG/ETO family and
whereof  the  core  ~75-80  residues  occur in TAF proteins. The transcription
initiation  TFIID  complex  is  composed  of  TATA binding protein (TBP) and a
number  of  TBP-associated factors (TAFs). The TAFH/NHR1 domain is named after
fruit  fly  TATA-box-associated  factor 110 (TAF110), human TAF105 and TAF130,
and the fruit fly protein Nervy, which is a homologue of human MTG8/ETO [1,2].
The human eight twenty-one (ETO or MTG8) and related myeloid transforming gene
products  MTGR1  and  MTG16  as  well  as the Nervy protein contain the NHR1-4
domains. The NHR1/TAFH domain occurs in the N-terminal part of these proteins,
while a MYND-type zinc finger (see <PDOC50865>) forms the NHR4 domain [3]. The
TAFH/NHR1  domain  can  be  involved  in  protein-protein interactions, e.g in
MTG8/ETO with HSP90 and Gfi-1 [4,5].

Some proteins known to contain a TAFH/NHR1 domain:

 - Mammalian  MTG8/ETO protein, which is involved in the t(8;21) form of acute
   myeloid leukemia and is an inhibitor of C/EBP beta in early adipogenesis.
 - Mammalian  myeloid  transforming  gene  (MTG)  or  eight  twenty-one  (ETO)
   proteins,  which  can  mediate  the protein complex formation among nuclear
   corepressors,   chromatin-modifying   enzymes  (HDACs),  and  transcription
   factors.
 - Drosophila  melanogaster  Nervy  protein,  a homologue of MTG8/ETO which is
   involved in neuronal development during segmentation of Drosophila embryos.
 - Drosophila  melanogaster  transcription  initiation  factor  TFIID  110 kDa
   subunit (TAF110) and mammalian homologue (TAFII130/135), which can interact
   with Sp1 and which may be a transcriptional coactivator.

The profile we developed covers the entire TAFH/NHR1 domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: May 2005 / First entry.

[ 1] Kitabayashi I., Ida K., Morohoshi F., Yokoyama A., Mitsuhashi N.,
     Shimizu K., Nomura N., Hayashi Y., Ohki M.
     "The AML1-MTG8 leukemic fusion protein forms a complex with a novel
     member of the MTG8(ETO/CDR) family, MTGR1."
     Mol. Cell. Biol. 18:846-858(1998).
     PubMed=9447981
[ 2] Calabi F., Cilli V.
     "CBFA2T1, a gene rearranged in human leukemia, is a member of a
     multigene family."
     Genomics 52:332-341(1998).
     PubMed=9790752
[ 3] Davis J.N., McGhee L., Meyers S.
     "The ETO (MTG8) gene family."
     Gene 303:1-10(2003).
     PubMed=12559562
[ 4] Komori A., Sueoka E., Fujiki H., Ishii M., Kozu T.
     "Association of MTG8 (ETO/CDR), a leukemia-related protein, with
     serine/threonine protein kinases and heat shock protein HSP90 in human
     hematopoietic cell lines."
     Jpn. J. Cancer Res. 90:60-68(1999).
     PubMed=10076566
[ 5] McGhee L., Bryan J., Elliott L., Grimes H.L., Kazanjian A.,
     Davis J.N., Meyers S.
     "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and
     histone deacetylase proteins, and represses transcription using a
     TSA-sensitive mechanism."
     J. Cell. Biochem. 89:1005-1018(2003).
     PubMed=12874834; DOI=10.1002/jcb.10548

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