{PDOC51126}
{PS51126; DILUTE}
{BEGIN}
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* Dilute domain profile *
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The  myosin  superfamily  consists of at least 15 distinct classes of presumed
actin-based  molecular  motors. All members of the superfamily share a similar
motor  domain  and  a  tail  portion which is diagnostic of the class [1].

Class  V  myosins are actin-based molecular motors that function in relatively
long-range  movements  of  many  intracellular  cargoes  including organelles,
membrane  vesicles,  and  mRNA [2]. These motors are ubiquitously found in all
eukaryotes.  Class  V myosins are characterised by the presence of a conserved
globular  domain at the C-terminus of the tail portion: the dilute domain [3].
Myosin  V  moves  via  attachment of its amino terminal head (motor) domain to
actin  cables;  its  carboxyl terminal dilute domain anchors it to cargoes via
attachments to organelle-specific receptors [2,4].

The  dilute  domain is also found in the afadin family. Afadins are nectin and
actin  filament-binding proteins that connect nectin to the actin cytoskeleton
[5].

The profile we developed covers the whole dilute domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: June 2005 / First entry.

[ 1] Oliver T.N., Berg J.S., Cheney R.E.
     "Tails of unconventional myosins."
     Cell. Mol. Life Sci. 56:243-257(1999).
     PubMed=11212352
[ 2] Catlett N.L., Duex J.E., Tang F., Weisman L.S.
     "Two distinct regions in a yeast myosin-V tail domain are required for
     the movement of different cargoes."
     J. Cell Biol. 150:513-526(2000).
     PubMed=10931864
[ 3] Ponting C.P.
     "AF-6/cno: neither a kinesin nor a myosin, but a bit of both."
     Trends Biochem. Sci. 20:265-266(1995).
     PubMed=7667878
[ 4] Pashkova N., Catlett N.L., Novak J.L., Wu G., Lu R., Cohen R.E.,
     Weisman L.S.
     "Myosin V attachment to cargo requires the tight association of two
     functional subdomains."
     J. Cell Biol. 168:359-364(2005).
     PubMed=15684027; DOI=10.1083/jcb.200407146
[ 5] Takai Y., Nakanishi H.
     "Nectin and afadin: novel organizers of intercellular junctions."
     J. Cell Sci. 116:17-27(2003).
     PubMed=12456712

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