{PDOC51137}
{PS51137; VM}
{BEGIN}
*********************
* VM domain profile *
*********************

In Drosophila  melanogaster  the vitelline membrane (VM) is the first layer of
the eggshell produced by the follicular epithelium. It is composed of at least
four different  proteins.  VM  proteins are similarly organized with a central
highly conserved  38-amino  acid domain which is flanked by unrelated regions.
Since the surrounding regions have diverged significantly, it is possible that
the VM domain is of key importance in VM protein structure [1,2].

The profile we developed covers the entire VM domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: June 2005 / First entry.

[ 1] Scherer L.J., Harris D.H., Petri W.H.
     "Drosophila vitelline membrane genes contain a 114 base pair region of
     highly conserved coding sequence."
     Dev. Biol. 130:786-788(1988).
     PubMed=3143615
[ 2] Scherer L.J., Harris D.H., White M.K., Steel L.F., Jin J., Petri W.H.
     "Comparative analysis of the sequence and structure of two Drosophila
     melanogaster genes encoding vitelline membrane proteins."
     Gene 136:121-127(1993).
     PubMed=8293994

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}