{PDOC51156} {PS51156; ELM2} {BEGIN} *********************** * ELM2 domain profile * *********************** The ELM2 (EGL-27 and MTA1 homology) domain was first described in Egl-27, a Caenorhabditis elegans protein that plays a fundamental role in patterning during embryonic development [1]. Most ELM2 domain-containing proteins also possess a SANT domain, implying a structural and/or functional relationship between these two motifs. Many proteins containing an ELM2 domain are known components of characterized transcription- and chromatin-regulatory complexes containing one or more histone deacetylases (HDACs). The evolutionarily conserved ELM2 domain has been shown to function as a transcriptional repression domain through recruitment of HDAC activity [2]. Some proteins known to contain a ELM2 domain are listed below: - Vertebrate mesoderm induction early response 1 (MI-ER1), a nuclear protein that contains an N-terminal acidic domain with potent transcriptional activity. - Vertebrate CoREST, a developmental regulator. - Mammalian metastasis-associated protein MTA1, a component of the NURD complex, which has histone deacetylase and ATP-dependent nucleosome remodelling activities. - Mammalian metastasis-associated protein MTA2, a component of a chromatin regulatory complex. - Mammalian metastasis-associated protein MTA3. - Drosophila melanogaster MTA1-like. - Drosophila melanogaster GRUNGE (Gug). - Drosophila melanogaster transcriptional corepressor Atro. - Caenorhabditis elegans Egl-27 and Egr-1. They are redundantly required for embryonic patterning. The profile we developed covers the entire extended ELM2 domain [2]. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: October 2005 / First entry. [ 1] Solari F., Bateman A., Ahringer J. "The Caenorhabditis elegans genes egl-27 and egr-1 are similar to MTA1, a member of a chromatin regulatory complex, and are redundantly required for embryonic patterning." Development 126:2483-2494(1999). PubMed=10226007 [ 2] Ding Z., Gillespie L.L., Paterno G.D. "Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain." Mol. Cell. Biol. 23:250-258(2003). PubMed=12482978 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}