{PDOC51207}
{PS51207; PXA}
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* PXA domain profile *
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The PX-associated  (PXA)  domain  is  a  ~200-amino  acid  module  of  unknown
function. Perhaps  it  is  required  for  protein-protein  interaction  and/or
filament formation.  In  addition  to  the  phosphoinositide-binding  PX  (see
<PDOC50195>) domain,   the   PXA   domain   can  also  be  associated  with  a
transmembrane domain  and  RGS  (see <PDOC50132>), which binds to activated G-
alpha subunits and is responsible for GTPase activating protein (GAP) function
[1,2].

Some proteins known to contain a PXA domain are listed below:

 - Mammalian sorting nexins (SNXs) 13, 14 and 19.
 - Yeast structural protein MDM1.

The profile we developed covers the entire PXA domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2006 / First entry.

[ 1] Zheng B., Ma Y.-C., Ostrom R.S., Lavoie C., Gill G.N., Insel P.A.,
     Huang X.-Y., Farquhar M.G.
     "RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular
     trafficking."
     Science 294:1939-1942(2001).
     PubMed=11729322; DOI=10.1126/science.1064757
[ 2] Xu Y., Seet L.-F., Hanson B., Hong W.
     "The Phox homology (PX) domain, a new player in phosphoinositide
     signalling."
     Biochem. J. 360:513-530(2001).
     PubMed=11736640

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