{PDOC51220} {PS51220; NIDO} {BEGIN} *********************** * NIDO domain profile * *********************** The ~180-residue NIDO domain is an extracellular domain of unknown function, found in nidogen (entactin) and hypothetical proteins. The NIDO domain is found in association with other domains, such as nidogen G2 beta-barrel (see ), thyroglobulin type-1 (see ), LDLRB (see ), AMOP (see ), EGF-like (see ), VWFD, IPT/TIG, or sushi/CCP/SCR (see ) [1-4]. Some proteins known to contain a NIDO domain are listed below: - Vertebrate nidogen-1 (NID-1) or entactin, a sulfated glycoprotein widely distributed in basement membranes. - Vertebrate nidogen-2 (NID-2) or osteonidogen, a cell adhesion glycoprotein which is widely distributed in basement membranes. - Vertebrate alpha-tectorin. - Mammalian mucin-4 (MUC4), a highly glycosylated membrane-bound protein. - Xenopus ID14, a putative matrix protein. The profile we developed covers the entire NIDO domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: June 2006 / First entry. [ 1] Ciccarelli F.D., Doerks T., Bork P. "AMOP, a protein module alternatively spliced in cancer cells." Trends Biochem. Sci. 27:113-115(2002). PubMed=11893501 [ 2] Desseyn J.-L., Clavereau I., Laine A. "Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4." Eur. J. Biochem. 269:3150-3159(2002). PubMed=12084055 [ 3] Buchholz D.R., Ishizuya-Oka A., Shi Y.-B. "Spatial and temporal expression pattern of a novel gene in the frog Xenopus laevis: correlations with adult intestinal epithelial differentiation during metamorphosis." Gene Expr. Patterns 4:321-328(2004). PubMed=15053982; DOI=10.1016/j.modgep.2003.10.005 [ 4] Duraisamy S., Ramasamy S., Kharbanda S., Kufe D. "Distinct evolution of the human carcinoma-associated transmembrane mucins, MUC1, MUC4 AND MUC16." Gene 373:28-34(2006). PubMed=16500040; DOI=10.1016/j.gene.2005.12.021 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}