{PDOC51229} {PS51229; DCUN1} {BEGIN} ************************ * DCUN1 domain profile * ************************ The DCUN1 domain is an ~190-residue module found in the eukaryotic defective in cullin neddylation (DCN) protein family, which includes: - Yeast DCN1. - Vertebrate DCN1-like protein 1. - Vertebrate DCN1-like protein 2. - Vertebrate DCN1-like protein 4. Proteins of the DCN family may contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes, which are multi-protein complexes required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome [1]. Although the DCUN1 domain function is unknown, it has been suggested that it has features of a basic helix-loop-helix leucine zipper (bHLH-ZIP) domain [2]. The DCUN1 domain can be found in association with an UBA-like domain [1]. The profile we developed covers the entire DCUN1 domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: July 2006 / First entry. [ 1] Kurz T., Oezlu N., Rudolf F., O'Rourke S.M., Luke B., Hofmann K., Hyman A.A., Bowerman B., Peter M. "The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae." Nature 435:1257-1261(2005). PubMed=15988528; DOI=10.1038/nature03662 [ 2] Pourcel C., Jaubert J., Hadchouel M., Wu X., Schweizer J. "A new family of genes and pseudogenes potentially expressing testis- and brain-specific leucine zipper proteins in man and mouse." Gene 249:105-113(2000). PubMed=10831844 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}