{PDOC51237}
{PS51268; ARAG}
{PS51246; CBIO}
{PS51243; CCMA}
{PS51237; CYSA}
{PS51242; FBPC}
{PS51261; HMUV}
{PS51244; LOLD}
{PS51267; MACB}
{PS51245; MALK}
{PS51264; METN}
{PS51260; MGLA}
{PS51241; MODC}
{PS51239; MSBA}
{PS51317; NDVA}
{PS51247; NIKD}
{PS51248; NIKE}
{PS51240; NODI}
{PS51249; PHNC}
{PS51305; POTA}
{PS51238; PSTB}
{PS51254; RBSA}
{PS51291; SSUB}
{PS51251; TAGH}
{PS51250; TAUB}
{PS51288; THIQ}
{PS51315; UGPC}
{PS51280; XYLG}
{PS51298; ZNUC}
{BEGIN}
***********************************
* ABC transporter family profiles *
***********************************

ABC  transporters  belong  to the ATP-Binding Cassette (ABC) superfamily which
use the hydrolysis of ATP to energize diverse biological systems. It forms one
of  the  largest  of  all  protein  families with a diversity of physiological
functions  (see <PDOC00185>) [1,2]. Several studies have shown that there is a
correlation  between  the  functional  characterisation  and  the phylogenetic
classification  of  the  ABC  cassette  [2,4]. More than 50 families have been
described based on a phylogenetic and functional classification [2,3,4] [E1].

Some  ABC  transporter  families  on  which  we developed a profile are listed
below.

Active import transport system components:

 - Sulfate/thiosulfate import ATP-binding protein cysA (EC 3.6.3.25).
 - Phosphate import ATP-binding protein pstB (EC 3.6.3.27).
 - Molybdenum import ATP-binding protein modC (EC 3.6.3.29).
 - Ferric cations import ATP-binding protein fbpC (EC 3.6.3.30).
 - Maltose/maltodextrin import ATP-binding protein malK (EC 3.6.3.19).
 - Cobalt import ATP-binding protein cbiO.
 - Nickel import ATP-binding protein nikD/nikE (EC 3.6.3.24).
 - Phosphonates import ATP-binding protein phnC (EC 3.6.3.28).
 - Taurine import ATP-binding protein tauB (EC 3.6.3.36).
 - Ribose import ATP-binding protein rbsA (EC 3.6.3.17).
 - Galactose/methyl galactoside import ATP-binding protein mglA (EC 3.6.3.17).
 - Hemin import ATP-binding protein hmuV.
 - Methionine import ATP-binding protein metN.
 - Arabinose import ATP-binding protein araG (EC 3.6.3.17).
 - Xylose import ATP-binding protein xylG (EC 3.6.3.17).
 - Thiamine import ATP-binding protein thiQ.
 - Aliphatic sulfonate import ATP-binding protein ssuB.
 - Zinc import ATP-binding protein znuC.
 - Spermidine/putrescine import ATP-binding protein potA (EC 3.6.3.31).
 - sn-glycerol-3-phosphate import ATP-binding protein ugpC (EC 3.6.3.20).

Active export transport system components:

 - Lipid A export ATP-binding/permease protein msbA.
 - Nod factor export ATP-binding protein I.
 - Cytochrome c biogenesis ATP-binding export protein ccmA (EC 3.6.3.41).
 - Lipoprotein releasing system ATP-binding protein lolD.
 - Teichoic acids export ATP-binding protein tagH (EC 3.6.3.40).
 - Macrolide export ATP-binding/permease protein macB.
 - Beta-(1-->2)glucan export ATP-binding/permease protein ndvA (EC 3.6.3.42).

Each  family  profile  was  built on a discriminating region either in the ABC
cassette or in the C-terminal region.

-Last update: June 2009 / Text revised.

[ 1] Holland I.B., Cole S.P.C., Kuchler K., Higgins C.F.
     (In) ABC proteins from bacteria to man, Academic Press, San Diego,
     (2003).
[ 2] Saurin W., Hofnung M., Dassa E.
     "Getting in or out: early segregation between importers and exporters
     in the evolution of ATP-binding cassette (ABC) transporters."
     J. Mol. Evol. 48:22-41(1999).
     PubMed=9873074
[ 3] Higgins C.F.
     "ABC transporters: physiology, structure and mechanism -- an overview."
     Res. Microbiol. 152:205-210(2001).
     PubMed=11421269
[ 4] Dassa E., Bouige P.
     "The ABC of ABCS: a phylogenetic and functional classification of ABC
     systems in living organisms."
     Res. Microbiol. 152:211-229(2001).
     PubMed=11421270
[E1] http://www.tcdb.org/tcdb/index.php?tc=3.A.1

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