{PDOC51284}
{PS51284; DOC}
{BEGIN}
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* DOC domain profile *
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The anaphase-promoting  complex  (APC) is a multi-subunit E3 protein ubiquitin
ligase that  is  reponsible  for  the metaphase to anaphase transition and the
exit from  mitosis.  The subunit APC10 is a one-domain protein homologous to a
sequence element,  termed  the  DOC  domain,  found  in  several  hypothetical
proteins that  may also mediate ubiquitination reactions, because they contain
combinations of either RING finger (see <PDOC00449>), cullin (see <PDOC00967>)
or HECT (see <PDOC50237>) domains [1-3].

The DOC   domain  consists  of  a  beta-sandwich,  in  which  a  five-stranded
antiparallel beta-sheet  is  packed  on  top  of a three stranded antiparallel
beta-sheet, exhibiting a 'jellyroll' fold (see <PDB:1JHJ; A>) [2,3].

Some proteins known to contain a DOC domain are listed below:

 - Eucaryotic Doc1/Apc10.
 - Mammalian protein associated with the transcription factor Myc (PAM).
 - Mouse runty-jerky-sterile (RJS) protein.
 - Human HERC2, the ortholog of RJS.

The profile we developed covers the entire DOC domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: January 2007 / First entry.

[ 1] Grossberger R., Gieffers C., Zachariae W., Podtelejnikov A.V.,
     Schleiffer A., Nasmyth K., Mann M., Peters J.-M.
     "Characterization of the DOC1/APC10 subunit of the yeast and the human
     anaphase-promoting complex."
     J. Biol. Chem. 274:14500-14507(1999).
     PubMed=10318877
[ 2] Wendt K.S., Vodermaier H.C., Jacob U., Gieffers C., Gmachl M.,
     Peters J.-M., Huber R., Sondermann P.
     "Crystal structure of the APC10/DOC1 subunit of the human
     anaphase-promoting complex."
     Nat. Struct. Biol. 8:784-788(2001).
     PubMed=11524682; DOI=10.1038/nsb0901-784
[ 3] Au S.W.N., Leng X., Harper J.W., Barford D.
     "Implications for the ubiquitination reaction of the anaphase-promoting
     complex from the crystal structure of the Doc1/Apc10 subunit."
     J. Mol. Biol. 316:955-968(2002).
     PubMed=11884135; DOI=10.1006/jmbi.2002.5399

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