{PDOC51289}
{PS51289; GLG1_C_RICH}
{BEGIN}
*****************************
* Cysteine-rich GLG1 repeat *
*****************************

The  Golgi  apparatus  protein 1 (GLG1), which is located in Golgi cisterns of
various  cell types, can bind fibroblast growth factor and E-selectin. Sixteen
cysteine-rich GLG1 repeats form the core of the protein and are located in the
lumen. The C-terminal part of GLG1 is composed of a transmembrane region and a
short  cytoplasmic  tail.  The Cys-rich GLG1 repeat is a ~60 amino acid module
that  contains  4  Cys  residues,  which can form intrachain disulfide bridges
[1,2].  Homologues  of  the  vertebrate  GLG1/Golgi  sialoglycoprotein  MG-160
(Mg160)/E-selectin  ligand  1  (ESL1)/cysteine-rich  fibroblast  growth factor
receptor  1  (CFR1)/latent  transforming  growth factor-beta complex protein 1
(LTCP-1) have been found in insects and the nematode Caenorhabditis elegans.

The profile we developed covers the entire cysteine-rich GLG1 repeat.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: January 2007 / First entry.

[ 1] Burrus L.W., Zuber M.E., Lueddecke B.A., Olwin B.B.
     "Identification of a cysteine-rich receptor for fibroblast growth
     factors."
     Mol. Cell. Biol. 12:5600-5609(1992).
     PubMed=1448090
[ 2] Kawano J., Nakayama T., Kotani T., Matsubayashi H., Yamamoto M.T.,
     Suganuma T.
     "Identification and characterization of an insect homologue of the
     vertebrate Golgi apparatus protein 1 (MG-160/cysteine-rich fibroblast
     growth factor receptor/E-selectin ligand-1/latent transforming growth
     factor-beta complex protein-1) with a Golgi-specific monoclonal
     antibody."
     Histochem. Cell Biol. 117:381-389(2002).
     PubMed=12029485; DOI=10.1007/s00418-002-0402-6

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}