{PDOC51299}
{PS51299; HTH_APSES}
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* APSES-type HTH DNA-binding domain profile *
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The APSES  (ASM-1,  Phd1,  StuA,  EFG1,  and  Sok2)  domain is an ~110-residue
sequence-specific DNA-binding domain found in a family of fungal transcription
factors that  regulate development or cell cycle progression. The APSES domain
is found   associated   with   ankyrin   repeats   (see   <PDOC50088>)  and  a
heterodimerization domain [1,2].

The APSES  domain consists of a six-stranded beta-sheet segment folded against
two pairs  of  alpha-helices  in  the  topology of the winged helix-turn-helix
(HTH) family  of  proteins  (see  <PDB:1L3G>).  The alphaA/alphaB helical pair
corresponds to the HTH motif [3-5].

Some proteins known to contain an APSES domain are listed below:

 - Saccharomyces  cerevisiae  Mlu-1  box  binding protein (MBP1), a cell cycle
   transcription factor.
 - Schizosaccharomyces  pombe  cell  division cycle-related proteins res1/sct1
   and res2/pct1, which are homologous to MBP1.
 - Schizosaccharomyces pombe start control protein cdc10.
 - Emericella   nidulans   (Aspergillus   nidulans)  cell  pattern  formation-
   associated protein    stuA.    It    regulates    the   transformation   of
   undifferentiated hyphal elements into a complex multicellular structure.
 - Saccharomyces cerevisiae transcription factor PHD1.
 - Saccharomyces  cerevisiae  protein  SOK2.  It represses the transition from
   unicellular growth to pseudohyphae.
 - Candida albicans enhanced filamentous growth protein (EFG1).
 - Neurospora  crassa ascospore maturation 1 protein (Asm-1). It has a role in
   spore maturation.

The profile we developed covers the entire APSES domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: March 2007 / First entry.

[ 1] Aramayo R., Peleg Y., Addison R., Metzenberg R.
     "Asm-1+, a Neurospora crassa gene related to transcriptional
     regulators of fungal development."
     Genetics 144:991-1003(1996).
     PubMed=8913744
[ 2] Dutton J.R., Johns S., Miller B.L.
     "StuAp is a sequence-specific transcription factor that regulates
     developmental complexity in Aspergillus nidulans."
     EMBO J. 16:5710-5721(1997).
     PubMed=9312029; DOI=10.1093/emboj/16.18.5710
[ 3] Xu R.-M., Koch C., Liu Y., Horton J.R., Knapp D., Nasmyth K., Cheng X.
     "Crystal structure of the DNA-binding domain of Mbp1, a transcription
     factor important in cell-cycle control of DNA synthesis."
     Structure 5:349-358(1997).
     PubMed=9083114
[ 4] Taylor I.A., Treiber M.K., Olivi L., Smerdon S.J.
     "The X-ray structure of the DNA-binding domain from the Saccharomyces
     cerevisiae cell-cycle transcription factor Mbp1 at 2.1 A resolution."
     J. Mol. Biol. 272:1-8(1997).
     PubMed=9299332; DOI=10.1006/jmbi.1997.1229
[ 5] Nair M., McIntosh P.B., Frenkiel T.A., Kelly G., Taylor I.A.,
     Smerdon S.J., Lane A.N.
     "NMR structure of the DNA-binding domain of the cell cycle protein
     Mbp1 from Saccharomyces cerevisiae."
     Biochemistry 42:1266-1273(2003).
     PubMed=12564929; DOI=10.1021/bi0205247

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