{PDOC51301} {PS51301; KILA_N} {BEGIN} *****"******************* * KilA-N domain profile * ************************* The amino-terminal module of the poxvirus D6R/NIR proteins defines a novel conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses [1]. Putative proteins with homology to the KilA-N domain have also been identified in Maverick transposable elements of the parabasalid protozoa Trichomonas vaginalis [2]. The KilA-N domain has been suggested to be homologous to the fungal DNA-binding APSES domain (see ). In all proteins shown to contain the KilA-N domain, it occurs at the extreme amino terminus accompanied by a wide range of distinct carboxy-terminal domains. These carboxy-terminal modules may be enzymes, such as the nuclease domains, or might mediate additional, specific interactions with nucleic acids or proteins, like the RING (see ) or CCCH fingers in the poxviruses [1]. The KilA-N domain is predicted to adopt an alpha+beta fold with four conserved strands and at least two conserved helices [1]. Some proteins known to contain a KilA-N domain are listed below: - Bacteriophage P1 protein kilA. - Fowlpox virus (FPV) protein FPV236. - Fowlpox virus (FPV) hypothetical protein FPV248. - Vaccinia virus hypothetical 21.7 kDa HindIII-C protein. The profile we developed covers the entire KilA-N domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: March 2007 / First entry. [ 1] Iyer L.M., Koonin E.V., Aravind L. "Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors." Genome Biol. 3:RESEARCH0012-RESEARCH0012(2002). PubMed=11897024 [ 2] Pritham E.J., Putliwala T., Feschotte C. "Mavericks, a novel class of giant transposable elements widespread in eukaryotes and related to DNA viruses." Gene 390:3-17(2007). PubMed=17034960; DOI=10.1016/j.gene.2006.08.008 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}