{PDOC51329}
{PS51329; C_CAP_COFACTOR_C}
{BEGIN}
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* C-CAP/cofactor C-like domain profile *
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The C-CAP/cofactor  C-like  domain  is present in several cytoskeleton-related
proteins, which also contain a number of additional domains [1-4]:

 - Eukaryotic   cyclase-associated  protein (CAP or SRV2) (see <PDOC00835>), a
   modular actin monomer binding that directly regulates filament dynamics and
   has been  implicated in a number of complex developmental and morphological
   processes, including  mRNA  localization  and  the  establishment  of  cell
   polarity.
 - Vertebrate retinitis pigmentosa 2 (XRP2). In human, the protein responsible
   for X-linked  forms  of  retinitis  pigmentosa,  a disease characterized by
   severe retinal degeneration.
 - Eukaryotic   tubulin-specific   chaperone  cofactor  C  (TBCC),  a  GTPase-
   activating component of the tubulin-folding supercomplex, which directs the
   assembly of the alpha- and beta-tubulin heterodimer.

The cyclase-associated  protein C-CAP/cofactor C-like domain binds G-actin and
is responsible for oligomerization of the entire CAP molecule [1], whereas the
XRP2 C-CAP/cofactor  C-like domain is required for binding of ADP ribosylation
factor-like protein 3 (Arl3) [2].

The central  core of the C-CAP/cofactor C-like domain is composed of six coils
of right-handed   parallel   beta-helix,  termed  coils  1-6,  which  form  an
elliptical barrel  with  a  tightly packed interior. Each beta-helical coil is
composed of  three relatively short beta-strands, designated a-c, separated by
sharp turns.  Flanking  the  central  beta-helical core is an N-terminal beta-
strand, beta0,  that  packs  antiparallel  to the core, and strand beta7 packs
antiparallel to  the  core  near the C-terminal end of the parallel beta-helix
(see <PDB:1K4Z>) [1,2].

The profile we developed covers the C-CAP/cofactor C-like domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: August 2007 / First entry.

[ 1] Dodatko T., Fedorov A.A., Grynberg M., Patskovsky Y., Rozwarski D.A.,
     Jaroszewski L., Aronoff-Spencer E., Kondraskina E., Irving T.,
     Godzik A., Almo S.C.
     "Crystal structure of the actin binding domain of the
     cyclase-associated protein."
     Biochemistry 43:10628-10641(2004).
     PubMed=15311924; DOI=10.1021/bi049071r
[ 2] Kuehnel K., Veltel S., Schlichting I., Wittinghofer A.
     "Crystal structure of the human retinitis pigmentosa 2 protein and its
     interaction with Arl3."
     Structure 14:367-378(2006).
     PubMed=16472755; DOI=10.1016/j.str.2005.11.008
[ 3] Stephan A., Vaughan S., Shaw M.K., Gull K., McKean P.G.
     "An Essential Quality Control Mechanism at the Eukaryotic Basal Body
     Prior to Intraflagellar Transport."
     Traffic 0:0-0(2007).
     PubMed=17645436; DOI=10.1111/j.1600-0854.2007.00611.x
[ 4] Grynberg M., Jaroszewski L., Godzik A.
     "Domain analysis of the tubulin cofactor system: a model for tubulin
     folding and dimerization."
     BMC Bioinformatics 4:46-46(2003).
     PubMed=14536023; DOI=10.1186/1471-2105-4-46

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