{PDOC51335}
{PS51335; ELMO}
{BEGIN}
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* ELMO domain profile *
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Regulatory GTPases  in  the  Ras superfamily employ a cycle of alternating GTP
binding and  hydrolysis, controlled by guanine nucleotide exchange factors and
GTPase-activating proteins  (GAPs),  as essential features of their actions in
cells. Within  the  Ras superfamily, the Arf family is composed of 30 members,
including 22  Arf-like  (Arl)  proteins.  The  ELMO  (for  EnguLfment and cell
MOtility) domain  has  been  proposed  to  be  a GAP domain for ARL2 and other
members of the Arf family [1].

The profile we developed covers the entire ELMO domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: October 2007 / First entry.

[ 1] Bowzard J.B., Cheng D., Peng J., Kahn R.A.
     "ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs."
     J. Biol. Chem. 282:17568-17580(2007).
     PubMed=17452337; DOI=10.1074/jbc.M701347200

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