{PDOC51366} {PS51366; MI} {BEGIN} ********************* * MI domain profile * ********************* The MI (after MA-3 and eIF4G) domain is a protein-protein interaction module of ~130 amino acids [1-3]. It appears in several translation factors and is found in: - One copy in plant and animal eIF4G 1 and 2 (DAP-5/NAT1/p97), - Two copies in the animal programmed cell death protein 4 (PDCD4) or MA-3 that is induced during programmed cell death and inhibits neoplastic transformation, - Four tandem-repeated copies in a group of uncharacterized plant proteins. The MI domain consists of seven alpha-helices, which pack into a globular form (see ). The packing arrangement consists of repeating pairs of antiparallel helices packed one upon the other such that a superhelical axis is generated perpendicular to the alpha-helical axes [4]. The profile we developed covers the entire MI domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Note: The MI domain has also been named MA3 domain. -Last update: February 2008 / First entry. [ 1] Aravind L., Koonin E.V. "Eukaryote-specific domains in translation initiation factors: implications for translation regulation and evolution of the translation system." Genome Res. 10:1172-1184(2000). PubMed=10958635 [ 2] Ponting C.P. "Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay." Trends. Biochem. Sci. 25:423-426(2000). PubMed=10973054 [ 3] Yang H.-S., Cho M.-H., Zakowicz H., Hegamyer G., Sonenberg N., Colburn N.H. "A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A." Mol. Cell. Biol. 24:3894-3906(2004). PubMed=15082783 [ 4] LaRonde-LeBlanc N., Santhanam A.N., Baker A.R., Wlodawer A., Colburn N.H. "Structural basis for inhibition of translation by the tumor suppressor Pdcd4." Mol. Cell. Biol. 27:147-156(2007). PubMed=17060447; DOI=10.1128/MCB.00867-06 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}