{PDOC51386} {PS51386; RINT1_TIP20} {BEGIN} ****************************** * RINT1/TIP20 domain profile * ****************************** The following proteins playing a role in anterograde transport from the endoplasmic reticulum (ER) to the Golgi and/or retrograde transport from the Golgi to the ER share sequence similarity: - Mammalian RINT1 (Rad50-interacting protein 1), which was originally discovered as a checkpoint protein that interacts with Rad50 only during late S and G2/M phases. RINT1 also functions in membrane trafficking from the endoplasmic reticulum (ER) to the Golgi complex in interphase cells [1-3]. - Yeast TIP20, which has been reported to be involved in the retrograde transport from the Golgi to the ER [4]. - Arabidopsis thaliana MAIGO2 (MAG2), functions in the transport of storage protein precursors between the ER and Golgi complex in plants [5]. They share a similar domain organization with an N-terminal leucine heptad repeat rich coiled coil and an ~500-residue C-terminal RINT1/TIP20 domain, which might be a protein-protein interaction module necessary for the formation of functional complexes. The profile we developed covers the entire RINT1/TIP20 domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: May 2008 / First entry. [ 1] Xiao J., Liu C.-C., Chen P.-L., Lee W.-H. "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control." J. Biol. Chem. 276:6105-6111(2001). PubMed=11096100; DOI=10.1074/jbc.M008893200 [ 2] Kong L.-J., Meloni A.R., Nevins J.R. "The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1." Mol. Cell 22:63-71(2006). PubMed=16600870; DOI=10.1016/j.molcel.2006.02.016 [ 3] Arasaki K., Taniguchi M., Tani K., Tagaya M. "RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex." Mol. Biol. Cell 17:2780-2788(2006). PubMed=16571679; DOI=10.1091/mbc.E05-10-0973 [ 4] Sweet D.J., Pelham H.R.B. "The TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p." EMBO J. 12:2831-2840(1993). PubMed=8334998 [ 5] Li L., Shimada T., Takahashi H., Ueda H., Fukao Y., Kondo M., Nishimura M., Hara-Nishimura I. "MAIGO2 is involved in exit of seed storage proteins from the endoplasmic reticulum in Arabidopsis thaliana." Plant Cell 18:3535-3547(2006). PubMed=17194767; DOI=10.1105/tpc.106.046151 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}