{PDOC51416}
{PS51416; MIB_HERC2}
{BEGIN}
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* MIB/HERC2 domain profile *
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The MIB/HERC2  domain is a conserved region of ~80 amino acids, which has been
identified in:

 - Animal Mind bomb 1 and 2 (MIB1 and MIB2) E3 ubiquitin ligases. They contain
   a very similar domain organization including an amino terminus ZZ-type zinc
   finger (see  <PDOC50135>)  surrounded by two MIB/HERC2 domains, followed by
   two MIB  specific  repeats, multiple ankyrin repeats (see <PDOC50088>), and
   two or  more  Ring fingers (see <PDOC00449>) at their C-terminal ends. They
   partake in   the  Notch  signaling  pathway  by  ubiquitinating  the  Notch
   receptors Delta and Jagged prior to endocytosis [1,2,3,4].
 - Animal probable E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-). It contains
   additional motifs,  including  RCC1 repeats (see <PDOC00544>), a DOC domain
   (see <PDOC51284>),  a carboxy-terminal HECT domain (see <PDOC50237>), and a
   ZZ-type zinc finger [5].

The profile we developed covers the entire MIB/HERC2 domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2008 / First entry.

[ 1] Itoh M., Kim C.-H., Palardy G., Oda T., Jiang Y.-J., Maust D., Yeo S.-Y.,
     Lorick K., Wright G.J., Ariza-McNaughton L., Weissman A.M., Lewis J.,
     Chandrasekharappa S.C., Chitnis A.B.
     "Mind bomb is a ubiquitin ligase that is essential for efficient
     activation of Notch signaling by Delta."
     Dev. Cell 4:67-82(2003).
     PubMed=12530964
[ 2] Koo B.-K., Yoon K.-J., Yoo K.-W., Lim H.-S., Song R., So J.-H., Kim C.-H.,
     Kong Y.-Y.
     "Mind bomb-2 is an E3 ligase for Notch ligand."
     J. Biol. Chem. 280:22335-22342(2005).
     PubMed=15824097; DOI=10.1074/jbc.M501631200
[ 3] Barsi J.C., Rajendra R., Wu J.I., Artzt K.
     "Mind bomb1 is a ubiquitin ligase essential for mouse embryonic
     development and Notch signaling."
     Mech. Dev. 122:1106-1117(2005).
     PubMed=16061358; DOI=10.1016/j.mod.2005.06.005
[ 4] Wu J.I., Rajendra R., Barsi J.C., Durfee L., Benito E., Gao G.,
     Kuruvilla M., Hrdlickova R., Liss A.S., Artzt K.
     "Targeted disruption of Mib2 causes exencephaly with a variable
     penetrance."
     Genesis 45:722-727(2007).
     PubMed=17987667; DOI=10.1002/dvg.20349
[ 5] Ji Y., Rebert N.A., Joslin J.M., Higgins M.J., Schultz R.A.,
     Nicholls R.D.
     "Structure of the highly conserved HERC2 gene and of multiple
     partially duplicated paralogs in human."
     Genome Res. 10:319-329(2000).
     PubMed=10720573

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