{PDOC51433} {PS51433; PNT} {BEGIN} ******************************** * Pointed (PNT) domain profile * ******************************** The highly conserved PNT (or Pointed) domain is found within a subset of the Ets transcription factors (see ), including mammalian Ets-1, Ets-2, Erg, Fli-1, GABPalpha, and Tel, as well as Drosophila Pnt-P2 and Yan. The PNT domain is structurally related to the larger group of SAM domains (see ) through a common tertiary arrangement of four alpha-helices (see ). A role in protein-protein association has been established for the PNT domain [1,2]. The profiles we developed cover the entire PNT domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: January 2009 / First entry. [ 1] Potter M.D., Buijs A., Kreider B., van Rompaey L., Grosveld G.C. "Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6." Blood 95:3341-3348(2000). PubMed=10828014 [ 2] Mackereth C.D., Schaerpf M., Gentile L.N., MacIntosh S.E., Slupsky C.M., McIntosh L.P. "Diversity in structure and function of the Ets family PNT domains." J. Mol. Biol. 342:1249-1264(2004). PubMed=15351649; DOI=10.1016/j.jmb.2004.07.094 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}