{PDOC51455}
{PS51455; PIPK}
{BEGIN}
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* Phosphatidylinositol phosphate kinase (PIPK) domain profile *
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Phosphoinositides (PIs)  are  central  to  signal  transduction  and  membrane
trafficking in  all  eukaryotes.  They  are  derived from phosphatidylinositol
(PtdIns) as the result of phosphorylation of hydroxyl groups at positions 3, 4
or 5  of the PtdIns head group. Phosphatidylinositol phosphate kinases (PIPKs)
phosphorylate phosphatidylinositol phosphate (PtdInsP) to phosphatidylinositol
bisphosphate (PtdInsP2).  Three  types  of  PIPKs  are  present throughout the
eukaryotic kingdoms.  Type  I  (PtdIns4P  5-kinase)  and  type II (PtdIns5P 4-
kinase) generate  PtdIns(4,5)P2 from PtdIns4P and PtdIns5P, respectively. Type
III PIPK  (PtdIns3P  5-kinases)  are distinct from the type I and II PIPKs and
synthesize PtdIns(3,5)P2 [1,2,3].

The basic structure of PIPKs shared by animals, yeast and plant PIPks consists
of a  highly  conserved  central kinase domain and a dimerization domain. PIPK
domains have   high  sequence  identity,  well-defined  motifs  and  conserved
residues. They  consist  of  two  alpha+beta  subdomains (see <PDB:1BO1>]. The
larger N-terminal  subdomain contains a seven-stranded antiparallel beta sheet
and four   helices.   The   C-terminal   subdomain  contains  a  five-stranded
antiparallel beta sheet and four helices [4].

The profile we developed covers the entire PIPK domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: June 2009 / First entry.

[ 1] Bakthavatsalam D., Meijer H.J.G., Noegel A.A., Govers F.
     "Novel phosphatidylinositol phosphate kinases with a G-protein coupled
     receptor signature are shared by Dictyostelium and Phytophthora."
     Trends Microbiol. 14:378-382(2006).
     PubMed=16876997; DOI=10.1016/j.tim.2006.07.006
[ 2] Heck J.N., Mellman D.L., Ling K., Sun Y., Wagoner M.P., Schill N.J.,
     Anderson R.A.
     "A conspicuous connection: structure defines function for the
     phosphatidylinositol-phosphate kinase family."
     Crit. Rev. Biochem. Mol. Biol. 42:15-39(2007).
     PubMed=17364683; DOI=10.1080/10409230601162752
[ 3] Saavedra L., Balbi V., Dove S.K., Hiwatashi Y., Mikami K.,
     Sommarin M.
     "Characterization of phosphatidylinositol phosphate kinases from the
     moss Physcomitrella patens: PpPIPK1 and PpPIPK2."
     Plant Cell Physiol. 50:595-609(2009).
     PubMed=19188261; DOI=10.1093/pcp/pcp018
[ 4] Rao V.D., Misra S., Boronenkov I.V., Anderson R.A., Hurley J.H.
     "Structure of type IIbeta phosphatidylinositol phosphate kinase: a
     protein kinase fold flattened for interfacial phosphorylation."
     Cell 94:829-839(1998).
     PubMed=9753329

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