{PDOC51460}
{PS51460; GAR}
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* GAR domain profile *
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The Gas2-related  (GAR) domain was named after Gas2 (growth arrest specific 2)
and is common in plakin family members and Gas2 family members. The GAR domain
comprises ~57 amino acids and has been shown to bind to microtubules [1,2].

Some proteins known to contain a GAR domain are listed below:

 - Mammalian  Gas2,  a  cytoskeletal  protein  that  is  highly upregulated in
   growth-arrested fibroblasts.
 - Mammalian Gas2-related on chromosome 22 (GAR22).
 - Mammalian MACF, a protein that can associate with both actin microfilaments
   and microtubules.
 - Mammalian bullous pemphigoid 1 (BPAG1).
 - Drosophila  Kakapo/Shortstop,  a  microtubule  and  microfilament organizer
   important for  axonal  outgrowth, local dendritic extension and maintaining
   the integrity of cell layers.
 - Drosophila protein CG3973, the homologue of Gas2.
 - Caenorhabditis elegans ZK1151, the orthologue of Kakapo/Short stop.

The profile we developed covers the entire GAR domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: March 2010 / First entry.

[ 1] Sun D., Leung C.L., Liem R.K.H.
     "Characterization of the microtubule binding domain of microtubule
     actin crosslinking factor (MACF): identification of a novel group of
     microtubule associated proteins."
     J. Cell Sci. 114:161-172(2001).
     PubMed=11112700
[ 2] Leung C.L., Green K.J., Liem R.K.H.
     "Plakins: a family of versatile cytolinker proteins."
     Trends Cell Biol. 12:37-45(2002).
     PubMed=11854008

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