{PDOC51492}
{PS51492; PEPTIDASE_C23}
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* Peptidase family C23 domain profile *
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Betaflexiviridae are  a  family  of plant viruses containing a single-stranded
positive-sense RNA  genome  [E1].  The  first  open  reading  frame  (ORF1) of
Betaflexiviridae encodes  a  putative  replication-associated  protein that is
autocatalytically processed  by  a  peptidase  family  C23  domain  [E2].  The
peptidase family  C23 domain is a papain-like proteinase domain with catalytic
cysteine and histidine residues [1].

Some proteins known to contain a peptidase family C23 domain are listed below:

 - Blueberry scorch virus (BBScV) RNA replication protein.
 - Apple stem pitting virus (ASPV) RNA replication protein.
 - Potato virus M (PVM) RNA replication protein.

The profile we developed covers the entire peptidase family C23 domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: November 2014 / First entry.

[ 1] Lawrence D.M., Rozanov M.N., Hillman B.I.
     "Autocatalytic processing of the 223-kDa protein of blueberry scorch
     carlavirus by a papain-like proteinase."
     Virology 207:127-135(1995).
     PubMed=7871721; DOI=10.1006/viro.1995.1058
[E1] https://viralzone.expasy.org/739?outline=all_by_species
[E2] https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=C23

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