{PDOC51503}
{PS51503; HIG1}
{BEGIN}
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* HIG1 domain profile *
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The hypoxia   induced   gene   1   (HIG1)  or  hypoglycemia/hypoxia  inducible
mitochondrial protein   (HIMP1)   is   up-regulated   by   stresses   of   the
microenvironment such  as  low  oxygen  or  low  glucose conditions. HIG1 is a
mitochondrial inner  membrane  protein, which is ubiquitously expressed. It is
predicted to  be  an  integral  membrane protein consisting of two hydrophobic
helices, 21-23  residues in length that might tend to form a hairpin-like loop
across the  bilayer.  HIG1  could  be  implied  in apoptotic or cytoprotective
signals. HIG1  is  a  member of a well conserved eukaryote protein family. The
predicted transmembrane  helice  (TMH)  and  loop  regions  represent the most
highly conserved regions in these proteins [1,2].

The profile we developed covers the predicted TMH and loop regions.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: August 2010 / First entry.

[ 1] Bedo G., Vargas M., Ferreiro M.-J., Chalar C., Agrati D.
     "Characterization of hypoxia induced gene 1: expression during rat
     central nervous system maturation and evidence of antisense RNA
     expression."
     Int. J. Dev. Biol. 49:431-436(2005).
     PubMed=15968589; DOI=10.1387/ijdb.041901gb
[ 2] Wang J., Cao Y., Chen Y., Chen Y., Gardner P., Steiner D.F.
     "Pancreatic beta cells lack a low glucose and O2-inducible
     mitochondrial protein that augments cell survival."
     Proc. Natl. Acad. Sci. U.S.A. 103:10636-10641(2006).
     PubMed=16815968; DOI=10.1073/pnas.0604194103

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