{PDOC51517} {PS51517; NDT80} {BEGIN} ************************************ * NDT80 DNA-binding domain profile * ************************************ The NDT80 DNA-binding domain is found in the following proteins, which might all be involved in sensing nutritional status [1]: - Yeast meiosis-specific transcription factor NDT80, the key transcription factor that ultimately allows the continuation of meiosis after the successful completion of recombination. - Emericella nidulans phoG (xprG), a transcriptional activator involved in the response to nutrient limitation. - Emericella nidulans putative uncharacterized protein AN6015.2. - Neurospora crassa transcription factor vib-1, involved in the control of heterokaryon incompatibility. - Neurospora crassa related to acid phosphatase NCU04729. - Neurospora crassa related to meiosis-specific protein NDT80 NCU09915. The proteolytically resistant core NDT80 DNA-binding domain reveals a central beta-sandwich characteristic of an s-type Ig fold (see ) (see ). The beta-sandwich contains a three-stranded sheet composed of strands a, b and e, packed against a four-stranded sheet composed of strands c', c, f and g. Each sheet of the beta-sandwich contains an additional beta- strand, as well as a variety of peripheral secondary structure elements. The NDT80 DNA-binding domain contains an N-terminal extension, which consists of a beta-hairpin and a loop [2]. The profile we developed covers the entire NDT80 DNA-binding domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: January 2011 / First entry. [ 1] Katz M.E., Gray K.-A., Cheetham B.F. "The Aspergillus nidulans xprG (phoG) gene encodes a putative transcriptional activator involved in the response to nutrient limitation." Fungal Genet. Biol. 43:190-199(2006). PubMed=16464624; DOI=10.1016/j.fgb.2005.12.001 [ 2] Lamoureux J.S., Stuart D., Tsang R., Wu C., Glover J.N.M. "Structure of the sporulation-specific transcription factor Ndt80 bound to DNA." EMBO J. 21:5721-5732(2002). PubMed=12411490 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}