{PDOC51518}
{PS51518; SGF29_C}
{BEGIN}
***********************************
* SGF29 C-terminal domain profile *
***********************************

Eukaryotic SGF29  is  a component of histone acetyltransferase (HAT) complexes
TATA-binding protein-free    TAF-containing    (TFTC)    and   SPT3-TAF9-GCN5-
acetyltransferase (STAGA)  or  SPT-ADA-GCN5-acetyltransferase  (SAGA) [1]. The
SGF29 C-terminal  domain  contains  a double Tudor-like motif that selectively
binds the  H3K4me2/3  lysine  methylation site on the N terminus of histone H3
[2,3].

Each Tudor  domain consists of five twisted anti-parallel beta strands forming
a typical  barrel-like fold (see <PDB:3MEA>). The tandem Tudor domains tightly
pack against  each  other  face-to-face  with  each  Tudor  domain harboring a
negatively charged   pocket   accommodating  the  first  residue  alanine  and
methylated K4 residue of histone H3, respectively [3].

The profile we developed covers the entire SGF29 C-terminal domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2011 / Profile and text revised.

[ 1] Kurabe N., Katagiri K., Komiya Y., Ito R., Sugiyama A., Kawasaki Y.,
     Tashiro F.
     "Deregulated expression of a novel component of TFTC/STAGA histone
     acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma:
     possible implication for the oncogenic potential of c-Myc."
     Oncogene 26:5626-5634(2007).
     PubMed=17334388; DOI=10.1038/sj.onc.1210349
[ 2] Vermeulen M., Eberl H.C., Matarese F., Marks H., Denissov S.,
     Butter F., Lee K.K., Olsen J.V., Hyman A.A., Stunnenberg H.G.,
     Mann M.
     "Quantitative interaction proteomics and genome-wide profiling of
     epigenetic histone marks and their readers."
     Cell 142:967-980(2010).
     PubMed=20850016; DOI=10.1016/j.cell.2010.08.020
[ 3] Bian C., Xu C., Ruan J., Lee K.K., Burke T.L., Tempel W., Barsyte D.,
     Li J., Wu M., Zhou B.O., Fleharty B.E., Paulson A., Allali-Hassani A.,
     Zhou J.-Q., Mer G., Grant P.A., Workman J.L., Zang J., Min J.
     "Sgf29 binds histone H3K4me2/3 and is required for SAGA complex
     recruitment and histone H3 acetylation."
     EMBO J. 30:2829-2842(2011).
     PubMed=21685874; DOI=10.1038/emboj.2011.193

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}