{PDOC51525}
{PS51525; NET}
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* NET domain profile *
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The bromodomain   and   extraterminal   (BET)   proteins   are   a   class  of
transcriptional regulators  whose  members can be found in animals, plants and
fungi. BET  proteins  are  involved  in  diverse  cellular  phenomena  such as
meiosis, cell-cycle  control, and homeosis and have been suggested to modulate
chromatin structure   and  affect  transcription  via  a  sequence-independent
mechanism. BET   proteins   are   defined   as  having  one  (plants)  or  two
(animals/yeast) bromodomains  (see    <PDOC00550>)  and an Extra Terminal (ET)
domain. The  ET  domain consists of three separate regions, only one of which,
the N-terminal  ET (NET) domain is conserved in all BET proteins. The function
of the NET domain is assumed to be protein binding [1,2,3,4].

The structure   of   the  NET  domain  comprises  three  alpha-helices  and  a
characteristic loop  region  of  an  irregular but well-defined structure (see
<PDB:2JNS>). The  NET  structure  has  an acidic patch that forms a continuous
ridge with  a hydrophobic cleft. which may interact with other proteins and/or
DNA [4].

Some proteins known to contain a NET domain are listed below:

 - Human RING3 (now designated Brd2)
 - Murine MCAP (now desihnated Brd4)
 - Drosophila Fsh
 - Yeast Bdf1 and Bdf2.
 - Arabidopsis imbibition-inducible (IMB1), plays a role in abscisic acid (ABA)
   and phytochrome A (phyA) mediated responses of seed germination.

The profile we developed covers the entire NET domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: July 2012 / First entry.

[ 1] Lygerou Z., Conesa C., Lesage P., Swanson R.N., Ruet A., Carlson M.,
     Sentenac A., Seraphin B.
     "The yeast BDF1 gene encodes a transcription factor involved in the
     expression of  a broad class of genes including snRNAs."
     Nucleic Acids Res. 22:5332-5340(1994).
     PubMed=7816623
[ 2] Florence B., Faller D.V.
     "You bet-cha: a novel family of transcriptional regulators."
     Front. Biosci. 6:D1008-D1018(2001).
     PubMed=11487468
[ 3] Duque P., Chua N.-H.
     "IMB1, a bromodomain protein induced during seed imbibition, regulates
     ABA-and phyA-mediated responses of germination in Arabidopsis."
     Plant. J. 35:787-799(2003).
     PubMed=12969431
[ 4] Lin Y.-J., Umehara T., Inoue M., Saito K., Kigawa T., Jang M.K.,
     Ozato K., Yokoyama S., Padmanabhan B., Guentert P.
     "Solution structure of the extraterminal domain of the
     bromodomain-containing protein BRD4."
     Protein Sci. 17:2174-2179(2008).
     PubMed=18815416; DOI=10.1110/ps.037580.108

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