{PDOC51532} {PS51532; PITH} {BEGIN} *********************** * PITH domain profile * *********************** The proteasome-interacting thioredoxin (PITH) domain is a general proteasome- interacting module [1]. The PITH domain is dominated by a jelly roll beta-sandwich structure (see ). The beta-sandwich is formed by face-to-face packing of two anti- parallel beta-sheets. Another two-stranded beta-sheet seals off one end of the beta-barrel [2,3]. Some proteins known to contain a PITH domain are listed below: - Human Txnl1 or TRP32, a thioredoxin-like protein implicated in endocytosis and in protection against glucose deprivation-induced cytotoxicity. - Human C1ORF28, an uncharacterized protein that does not contain any other known protein domains, but has been found to associate with 26S proteasomes. - Arabidopsis thaliana At3g04780, a single domain protein. The profile we developed covers the entire PITH domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: March 2011 / First entry. [ 1] Andersen K.M., Madsen L., Prag S., Johnsen A.H., Semple C.A., Hendil K.B., Hartmann-Petersen R. "Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome." J. Biol. Chem. 284:15246-15254(2009). PubMed=19349277; DOI=10.1074/jbc.M900016200 [ 2] Song J., Tyler R.C., Wrobel R.L., Frederick R.O., Vojtek F.C., Jeon W.B., Lee M.S., Markley J.L. "Solution structure of At3g04780.1-des15, an Arabidopsis thaliana ortholog of the C-terminal domain of human thioredoxin-like protein." Protein Sci. 14:1059-1063(2005). PubMed=15741346; DOI=10.1110/ps.041246805 [ 3] Goroncy A.K., Koshiba S., Tochio N., Tomizawa T., Inoue M., Tanaka A., Sugano S., Kigawa T., Yokoyama S. "Solution structure of the C-terminal DUF1000 domain of the human thioredoxin-like 1 protein." Proteins 78:2176-2180(2010). PubMed=20455272; DOI=10.1002/prot.22719 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}