{PDOC51545} {PS51545; PIK_HELICAL} {BEGIN} ************************************************************ * Phosphatidylinositol kinase (PIK) helical domain profile * ************************************************************ Phosphatidylinositol kinases are found in all eukaryotes and serve important functions in phosphatidylinositol (PI) signaling pathways. All PI3Ks and PI4Ks contain a conserved PI-kinase domain (see ), and most have various additional domains that are involved in protein-protein or phospholipid- protein interactions [1,2]. The phosphoinositide kinase (PIK) domain is a region conserved among all PI3 and PI4-kinases and although its role is presently unclear, it is likely to be involved in substrate presentation [3]. The PIK domain folds as an all alpha-helical structure (see ) [4]. The profile we developed covers the entire PIK helical domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: August 2011 / First entry. [ 1] Bosotti R., Isacchi A., Sonnhammer E.L. "FAT: a novel domain in PIK-related kinases." Trends Biochem. Sci. 25:225-227(2000). PubMed=10782091 [ 2] Meijer H.J.G., Govers F. "Genomewide analysis of phospholipid signaling genes in Phytophthora spp.: novelties and a missing link." Mol. Plant Microbe Interact. 19:1337-1347(2006). PubMed=17153918; DOI=10.1094/MPMI-19-1337 [ 3] Domin J., Waterfield M.D. "Using structure to define the function of phosphoinositide 3-kinase family members." FEBS Lett. 410:91-95(1997). PubMed=9247130 [ 4] Huang C.-H., Mandelker D., Schmidt-Kittler O., Samuels Y., Velculescu V.E., Kinzler K.W., Vogelstein B., Gabelli S.B., Amzel L.M. "The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations." Science 318:1744-1748(2007). PubMed=18079394; DOI=10.1126/science.1150799 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}