{PDOC51634}
{PS51634; CRC}
{BEGIN}
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* CRC domain profile *
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The following  proteins  of  the tesmin/TSO1 family contain two cysteines-rich
repeats with  the consensus C-X-C-X(4)-C-X(3)-Y-C-X-C-X(6)-C-X(3)-C-X-C-X(2)-C
separated by  a  region  of  variable  length  containing  the short conserved
sequence R-N-P-X-A-F-X-P-K:

 - Animal  tesmin or MTL5, originally identified by its specific expression in
   testes, but  subsequently  it was also detected at specific stages of ovary
   development.
 - Animal tesmin-like (tesl) or LIN54.
 - Drosophila  melanogaster  tombola (tomb), a meiotic arrest protein which is
   expressed specifically in testis.
 - Arabidopsis  thaliana TSO1, 'tso' means 'ugly' in Chinese and refers to the
   appearance of tso1 mutant flowers.
 - Arabidopsis thaliana TSO1-like 1 and 2 (SOL1 and SOL2).
 - Legume  Cysteine-rich Polycomb-like Protein 1 (CPP1), a DNA-binding protein
   acting as a negative regulator of the leghemoglobin gene.

This domain has been named the CRC domain (C1-RNPXAFXPK-C2). It binds zinc and
is able to bind DNA [1,2,3,4,5].

The CRC domain shows some similarity to the CXC domain found in the E(z)-type
of Polycomb group proteins (see <PDOC51633>) [6]. However, a clear distinction
can be made since the CXC domain lacks the RNPXAFXPK motif.

The profile we developed covers the entire CRC domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: January 2012 / First entry.

[ 1] Song J.-Y., Leung T., Ehler L.K., Wang C., Liu Z.
     "Regulation of meristem organization and cell division by TSO1, an
     Arabidopsis gene with cysteine-rich repeats."
     Development 127:2207-2217(2000).
     PubMed=10769244
[ 2] Hauser B.A., He J.Q., Park S.O., Gasser C.S.
     "TSO1 is a novel protein that modulates cytokinesis and cell expansion
     in Arabidopsis."
     Development 127:2219-2226(2000).
     PubMed=10769245
[ 3] Cvitanich C., Pallisgaard N., Nielsen K.A., Hansen A.C., Larsen K.,
     Pihakaski-Maunsbach K., Marcker K.A., Jensen E.O.
     "CPP1, a DNA-binding protein involved in the expression of a soybean
     leghemoglobin c3 gene."
     Proc. Natl. Acad. Sci. U.S.A. 97:8163-8168(2000).
     PubMed=10859345; DOI=10.1073/pnas.090468497
[ 4] Andersen S.U., Algreen-Petersen R.G., Hoedl M., Jurkiewicz A.,
     Cvitanich C., Braunschweig U., Schauser L., Oh S.-A., Twell D.,
     Jensen E.O.
     "The conserved cysteine-rich domain of a tesmin/TSO1-like protein
     binds zinc in vitro and TSO1 is required for both male and female
     fertility in Arabidopsis thaliana."
     J. Exp. Bot. 58:3657-3670(2007).
     PubMed=18057042; DOI=10.1093/jxb/erm215
[ 5] Jiang J., Benson E., Bausek N., Doggett K., White-Cooper H.
     "Tombola, a tesmin/TSO1-family protein, regulates transcriptional
     activation in the Drosophila male germline and physically interacts
     with always early."
     Development 134:1549-1559(2007).
     PubMed=17360778; DOI=10.1242/dev.000521
[ 6] Ogawa M., Hiraoka Y., Taniguchi K., Aiso S.
     "Cloning and expression of a human/mouse Polycomb group gene,
     ENX-2/Enx-2."
     Biochim. Biophys. Acta 1395:151-158(1998).
     PubMed=9473645

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