{PDOC51649}
{PS51649; NPH3}
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* NPH3 domain profile *
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The NRL  (for NPH3/RPT2-Like) family is formed by signaling molecules specific
to higher   plant.  Several  regions  of  sequence  and  predicted  structural
conservation define  members  of the NRL family, with three domains being most
notable: an  N-terminal BTB domain (see <PDOC50097>), a centrally located NPH3
domain, and  a  C-terminal coiled coil domain. The function of the NPH3 domain
is not yet known [1,2,3,4,5,6,7,8].

Some proteins known to contain a NPH3 domain are listed below:

 - Arabidopsis  non-phototropic hypocotyl 3 (NPH3), may function as an adapter
   or scaffold protein in plants.
 - Arabidopsis  root-phototropisme  2  (RPT2), a signal transducer involved in
   phototropic response and stomatal opening in association with phototropin 1
   (phot1).
 - Oriza  coleoptile  phototropism  1 (CPT1), the rice ortholog of NPH3. It is
   required for  phototropism  of  coleoptiles  and  lateral  translocation of
   auxin.

The profile we developed covers the entire NPH3 domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: July 2012 / First entry.

[ 1] Motchoulski A., Liscum E.
     "Arabidopsis NPH3: A NPH1 photoreceptor-interacting protein essential
     for phototropism."
     Science 286:961-964(1999).
     PubMed=10542152
[ 2] Sakai T., Wada T., Ishiguro S., Okada K.
     "RPT2. A signal transducer of the phototropic response in
     Arabidopsis."
     Plant Cell 12:225-236(2000).
     PubMed=10662859
[ 3] Inada S., Ohgishi M., Mayama T., Okada K., Sakai T.
     "RPT2 is a signal transducer involved in phototropic response and
     stomatal opening by association with phototropin 1 in Arabidopsis
     thaliana."
     Plant Cell 16:887-896(2004).
     PubMed=15031408; DOI=10.1105/tpc.019901
[ 4] Haga K., Takano M., Neumann R., Iino M.
     "The Rice COLEOPTILE PHOTOTROPISM1 gene encoding an ortholog of
     Arabidopsis NPH3 is required for phototropism of coleoptiles and
     lateral translocation of auxin."
     Plant Cell 17:103-115(2005).
     PubMed=15598797; DOI=10.1105/tpc.104.028357
[ 5] Pedmale U.V., Liscum E.
     "Regulation of phototropic signaling in Arabidopsis via
     phosphorylation state changes in the phototropin 1-interacting protein
     NPH3."
     J. Biol. Chem. 282:19992-20001(2007).
     PubMed=17493935; DOI=10.1074/jbc.M702551200
[ 6] Inoue S., Kinoshita T., Takemiya A., Doi M., Shimazaki K.
     "Leaf positioning of Arabidopsis in response to blue light."
     Mol. Plant 1:15-26(2008).
     PubMed=20031912; DOI=10.1093/mp/ssm001
[ 7] Holland J.J., Roberts D., Liscum E.
     "Understanding phototropism: from Darwin to today."
     J. Exp. Bot. 60:1969-1978(2009).
     PubMed=19357428; DOI=10.1093/jxb/erp113
[ 8] Roberts D., Pedmale U.V., Morrow J., Sachdev S., Lechner E., Tang X.,
     Zheng N., Hannink M., Genschik P., Liscum E.
     "Modulation of phototropic responsiveness in Arabidopsis through
     ubiquitination of phototropin 1 by the CUL3-Ring E3 ubiquitin ligase
     CRL3(NPH3)."
     Plant Cell 23:3627-3640(2011).
     PubMed=21990941; DOI=10.1105/tpc.111.087999

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