{PDOC51667}
{PS51667; WRC}
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* WRC domain profile *
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The plant  GROWTH-REGULATING  FACTOR (GRF) proteins are putative transcription
factors. They contain one or two WRC (Trp, Arg, Cys) domain(s). The WRC domain
has two  distinctive  structural  features, namely many basic amino acids (Arg
and Lys)  and the conserved spacing of three Cys and one His residues, the C3H
motif. The  basic  amino  acids are highly conserved, indicating that they are
essential for the function of the WRC domain, probably as nuclear localization
signal. The  C3H motif is also absolutely conserved and may mediate binding to
DNA [1].

The profile we developed covers the entire WRC domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2013 / Text revised.

[ 1] Kim J.H., Choi D., Kende H.
     "The AtGRF family of putative transcription factors is involved in
     leaf and cotyledon growth in Arabidopsis."
     Plant J. 36:94-104(2003).
     PubMed=12974814

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