{PDOC51673}
{PS51673; SUZ}
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* SUZ domain profile *
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The SUZ  domain  is  found  in  a  wide range of eukaryotes including animals,
fungi, Dictyostelium,  plants, and the apicomplexan Plasmodium falciparum. The
SUZ domain  shows  a  strong association with known RNA-binding domains: it is
fused with R3H (see <PDOC51061>) and RRM domains and RGG repeats in previously
characterized multidomain RNA-binding proteins:

 - Caenorhabditis  elegans SZY-20, a putative RNA-binding protein that plays a
   critical role in limiting centrosome size.
 - Drosophila Encore protein, required for the regulation of germline mitosis,
   karyosome formation, and establishment of dorsoventral (DS) polarity of the
   egg and embryo.
 - Maize Dip1 protein.
 - Mammalian R3H domain-containing protein 1 (R3HDM1).

Based on  the  "syntax"  of  the  domain architecture, the SUZ domain has been
predicted to  function  in connection to RNA-protein complexes. The SUZ domain
enrichment in   positively   charged   residues,  including  four  universally
conserved positively  charged positions, supports a role in direct RNA-binding
[1].

The profile we developed covers the entire SUZ domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2013 / First entry.

[ 1] Song M.H., Aravind L., Mueller-Reichert T., O'Connell K.F.
     "The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to
     limit centrosome size."
     Dev. Cell 15:901-912(2008).
     PubMed=19081077; DOI=10.1016/j.devcel.2008.09.018

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