{PDOC51674} {PS51674; 4FE4S_WBL} {BEGIN} ****************************************************************** * 4Fe-4S WhiB-like (Wbl)-type iron-sulfur binding domain profile * ****************************************************************** Members of the WhiB-like (Wbl) family are found exclusively in actinobacteria and are implicated in the regulation of developmental processes. All WhiB- like proteins have four conserved cysteine residues where two of them are in a C-X-X-C motif. The four cysteine residues are proposed to act as the ligands for a [4Fe-4S] cluster. Wbl-mediated transcription regulation is dependent upon the presence or absence and state (nitrosylated or non-nitrosylated) of the [4Fe-4S] cluster [1,2,3]. The profile we developed covers the entire Wbl-type 4Fe-4S domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: May 2013 / First entry. [ 1] Garg S.K., Suhail Alam M., Soni V., Radha Kishan K.V., Agrawal P. "Characterization of Mycobacterium tuberculosis WhiB1/Rv3219 as a protein disulfide reductase." Protein Expr. Purif. 52:422-432(2007). PubMed=17157031; DOI=10.1016/j.pep.2006.10.015 [ 2] den Hengst C.D., Buttner M.J. "Redox control in actinobacteria." Biochim. Biophys. Acta 1780:1201-1216(2008). PubMed=18252205; DOI=10.1016/j.bbagen.2008.01.008 [ 3] Smith L.J., Stapleton M.R., Buxton R.S., Green J. "Structure-function relationships of the Mycobacterium tuberculosis transcription factor WhiB1." PLoS ONE 7:E40407-E40407(2012). PubMed=22792304; DOI=10.1371/journal.pone.0040407 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}