{PDOC51692}
{PS51692; PESTIVIRUS_NS2_PRO}
{BEGIN}
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* Pestivirus nonstructural protein 2 (NS2) protease domain profile *
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Pestiviruses [E1] are animal pathogens that are recognized as a separate genus
of the  family Flaviviridae. The pestiviral genome is a single-stranded RNA of
positive polarity.  It  is  translated  into  a  large  polyprotein,  which is
cotranslationally and  posttranslationally  processed  by  viral  and cellular
proteases. Pestivirus  nonstructural  protein  2  (NS2) is predicted to have a
multidomain organization.  The  C-terminal-most  domain  of  NS2 is a cysteine
autoprotease responsible  for NS2-3 cleavage. The catalytic triad is formed by
His, Glu,  and  Cys.  The pestivirus NS2 protease domain contains five Cys and
one His   organized  in  a  linear  fashion,  suggesting  the  presence  of  a
mononuclear ZnB  site  [1]. The pestivirus NS2 protease domain forms peptidase
family C74 [E2].

The profile we developed covers the entire pestivirus NS2 protease domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: November 2013 / First entry.

[ 1] Lackner T., Mueller A., Pankraz A., Becher P., Thiel H.-J.,
     Gorbalenya A.E., Tautz N.
     "Temporal modulation of an autoprotease is crucial for replication and
     pathogenicity of an RNA virus."
     J. Virol. 78:10765-10775(2004).
     PubMed=15367643; DOI=10.1128/JVI.78.19.10765-10775.2004
[E1] https://viralzone.expasy.org/39?outline=all_by_species
[E2] https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=C74

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