{PDOC51708}
{PS51708; CHAD}
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* CHAD domain profile *
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The CHAD  (conserved  histidine  alpha-helical  domain)  is an uncharacterized
domain, with  a  characteristic  pattern  of  conserved  histidines  and other
charged residues. It is predicted to adopt an alpha-helical fold. The sequence
conservation pattern suggests that this domain is likely to contain two repeat
units, with  at  least  4  helices  each,  at  its core. The conserved charged
residues could form a strongly polar surface that could participate, either in
metal chelation, or act as phosphoacceptors [1].

Some proteins known to contain a CHAD domain are listed below:

 - Escherichia coli uncharacterized protein YgiF.
 - Mycobacterium tuberculosis uncharacterized protein Rv2226/MT2285.

The profile we developed covers the entire CHAD domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: February 2014 / First entry.

[ 1] Iyer L.M., Aravind L.
     "The catalytic domains of thiamine triphosphatase and CyaB-like
     adenylyl cyclase define a novel superfamily of domains that bind
     organic phosphates."
     BMC Genomics 3:33-33(2002).
     PubMed=12456267

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