{PDOC51716}
{PS51716; G_IRG}
{BEGIN}
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* IRG-type guanine nucleotide-binding (G) domain profile *
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The P-loop  (see  <PDOC00017>)  guanosine  triphosphatases (GTPases) control a
multitude of  biological  processes, ranging from cell division, cell cycling,
and signal  transduction,  to ribosome assembly and protein synthesis. GTPases
exert their  control  by interchanging between an inactive GDP-bound state and
an active  GTP-bound  state,  thereby acting as molecular switches. The common
denominator of  GTPases is the highly conserved guanine nucleotide-binding (G)
domain that is responsible for binding and hydrolysis of guanine nucleotides.

The p47  or  immunity-related  GTPases  (IRG)  are  at  least  as  old  as the
vertebrates. The  IRG proteins are an essential resistance system in the mouse
for immunity  against pathogens that enter the cell via a vacuole. Despite its
importance for  the  mouse,  the  IRG  resistance system is absent from humans
because it  has  been lost during the divergent evolution of the primates. The
IRG proteins appear to be accompanied phylogenetically by homologous proteins,
named 'quasi  IRG'  (IRGQ)  proteins, that probably lack nucleotide binding or
hydrolysis function, and that may form regulatory heterodimers with functional
IRG proteins.  The  region  of  lowest  similarity  is  in  the  G domain, and
conserved GTP-binding motifs are lacking [1,2,3].

The profile we developed covers the entire IRG-type G domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2014 / First entry.

[ 1] Leipe D.D., Wolf Y.I., Koonin E.V., Aravind L.
     "Classification and evolution of P-loop GTPases and related ATPases."
     J. Mol. Biol. 317:41-72(2002).
     PubMed=11916378; DOI=10.1006/jmbi.2001.5378
[ 2] Boehm U., Guethlein L., Klamp T., Ozbek K., Schaub A., Fuetterer A.,
     Pfeffer K., Howard J.C.
     "Two families of GTPases dominate the complex cellular response to
     IFN-gamma."
     J. Immunol. 161:6715-6723(1998).
     PubMed=9862701
[ 3] Bekpen C., Hunn J.P., Rohde C., Parvanova I., Guethlein L., Dunn D.M.,
     Glowalla E., Leptin M., Howard J.C.
     "The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of
     the cell autonomous resistance mechanism in the human lineage."
     Genome Biol. 6:R92-R92(2005).
     PubMed=16277747; DOI=10.1186/gb-2005-6-11-r92

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