{PDOC51723}
{PS51723; PEPTIDASE_M60}
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* Peptidase family M60 domain profile *
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The peptidase  family  M60  domain  belongs to the zincin superfamily of zinc-
requiring metalloproteases (clan MA, subclan MA(E)) [E1]. The peptidase family
M60 domain contains the metal-binding consensus motif HExxH. The two histidine
residues are  ligands of the catalytic Zn(2+) and the glutamic acid residue is
involved in  nucleophilic  attack.  An  additional  conserved glutamic acid is
found approximately  20  residues  from  the first histidine within the metal-
binding motif.  The second conserved glutamic acid potentially acts as a third
proteous Zn(2+)  ligand.  The peptidase family M60 domain targets complex host
glycoproteins, such as mucins [1,2,3,4,5].

Some proteins known to contain a peptidase family M60 domain are listed below:

 - Baculovirus  viral  enhancing  factor  (VEF),  also  known  as  Enhancin, a
   metalloprotease that  enhances viral infection by degrading the peritrophic
   membrane (PM) of the insect midgut.
 - Bacteria enhancin-like metalloproteases.
 - Mammalian FAM115 family proteins.

The profile we developed covers the entire peptidase family M60 domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: June 2014 / First entry.

[ 1] Bischoff D.S., Slavicek J.M.
     "Molecular analysis of an enhancin gene in the Lymantria dispar
     nuclear polyhedrosis virus."
     J. Virol. 71:8133-8140(1997).
     PubMed=9343163
[ 2] Galloway C.S., Wang P., Winstanley D., Jones I.M.
     "Comparison of the bacterial Enhancin-like proteins from Yersinia and
     Bacillus spp. with a baculovirus Enhancin."
     J. Invertebr. Pathol. 90:134-137(2005).
     PubMed=16081094; DOI=10.1016/j.jip.2005.06.008
[ 3] Hajaij-Ellouze M., Fedhila S., Lereclus D., Nielsen-LeRoux C.
     "The enhancin-like metalloprotease from the Bacillus cereus group is
     regulated by  the pleiotropic transcriptional activator PlcR but is
     not essential for larvicidal activity."
     FEMS Microbiol. Lett. 260:9-16(2006).
     PubMed=16790012; DOI=10.1111/j.1574-6968.2006.00289.x
[ 4] Toprak U., Harris S., Baldwin D., Theilmann D., Gillott C.,
     Hegedus D.D., Erlandson M.A.
     "Role of enhancin in Mamestra configurata nucleopolyhedrovirus
     virulence: selective degradation of host peritrophic matrix
     proteins."
     J. Gen. Virol. 93:744-753(2012).
     PubMed=22238230; DOI=10.1099/vir.0.038117-0
[ 5] Nakjang S., Ndeh D.A., Wipat A., Bolam D.N., Hirt R.P.
     "A novel extracellular metallopeptidase domain shared by animal
     host-associated mutualistic and pathogenic microbes."
     PLoS ONE 7:E30287-E30287(2012).
     PubMed=22299034; DOI=10.1371/journal.pone.0030287
[E1] https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=M60

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