{PDOC51737} {PS51737; RECOMBINASE_DNA_BIND} {BEGIN} ****************************************** * DNA-binding recombinase domain profile * ****************************************** The large serine recombinases (LSRs) are DNA-rearranging enzymes that are members of the serine recombinase or resolvase/invertase superfamily. Most resolvases/invertases have a catalytic domain of ~150 residues at their amino terminus (see ), followed by a small, helix-turn-helix (HTH) DNA- binding domain. The LSRs share a similar amino-terminal catalytic domain, but have much larger carboxyl-terminal regions that range in size from ~300 residues to ~550 residues. The C-terminal region of the LSRs is comprised of multiple structural domains and is responsible for coordination of unique LSRs activities. The LSR C-terminal region is composed of two structural domains: a mixed alpha/beta DNA-binding "recombinase domain" linked to an unusual DNA- binding zinc ribbon domain [1,2]. The DNA-binding recombinase domain is moderately well conserved among the LSRs and consists of a four stranded beta-sheet embedded in a core 4-helix bundle (see ) [1,2]. The profile we developed covers the entire DNA-binding recombinase domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: November 2014 / New entry. [ 1] Rutherford K., Yuan P., Perry K., Sharp R., Van Duyne G.D. "Attachment site recognition and regulation of directionality by the serine integrases." Nucleic Acids Res. 41:8341-8356(2013). PubMed=23821671; DOI=10.1093/nar/gkt580 [ 2] Van Duyne G.D., Rutherford K. "Large serine recombinase domain structure and attachment site binding." Crit. Rev. Biochem. Mol. Biol. 48:476-491(2013). PubMed=23980849; DOI=10.3109/10409238.2013.831807 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}