{PDOC51750}
{PS51750; BRO_N}
{BEGIN}
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* Bro-N domain profile *
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The baculovirus  Bro  proteins  are encoded by a multigene family. The typical
Bro proteins  that  have  been  experimentally investigated are BroA, BroC and
BroD from  Bombyx mori uclear polyhedrosis virus (BmNV). They contain distinct
amino- and  carboxy-terminal  domains (Bro-N and Bro-C, respectively) that are
present independently  of  each other and in distinct contexts in a variety of
other viral  proteins.  The  Bro-N  domain  occurs  in  a  stand-alone form or
combined with  other  domains  in  proteins  from temperate phages that infect
Gram-positive bacteria  and  Myxococcus  xanthus,  and proteins encoded in the
genomes of proteobacteria and Gram positive bacteria. The Bro-N domain appears
to define a distinct superfamily of widespread viral DNA-binding domains [1].

Multiple alignment-based  secondary-structure  prediction  of the Bro-N domain
reveals a  core  with two head-to-tail  units of a beta-hairpin followed by an
alpha-helix. The  multiple  alignment shows that the Bro-N domains contain two
highly conserved aromatic or hydrophobic residues at the end of the second and
forth conserved strands [1].

The profile we developed covers the entire Bro-N domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: March 2015 / First entry.

[ 1] Iyer L.M., Koonin E.V., Aravind L.
     "Extensive domain shuffling in transcription regulators of DNA viruses
     and implications for the origin of fungal APSES transcription
     factors."
     Genome Biol. 3:RESEARCH0012-RESEARCH0012(2002).
     PubMed=11897024

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