{PDOC51751}
{PS51751; EXPERA}
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* EXPERA domain profile *
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The EXPERA (EXPanded EBP superfamilly) domain is conserved among the following
protein families:

 - Vertebrate TM6SF1 (Transmembrane 6 Superfamily Member 1).
 - Vertebrate TM6SF2 (Transmembrane 6 Superfamily Member 2).
 - Eukaryotic  MAC30  (Meningioma-associated  protein 30) also known as TMEM97
   (Transmembrane protein  97),  mainly localized in the endoplasmic reticulum
   (ER).
 - Eukaryotic  EBP  (Emopamil binding protein), an enzyme with a D8, D7 sterol
   isomerase activity  that  catalyzes the transposition of a double bond from
   C8=C9 to C7=C8 in the sterol B-ring.

The EXPERA domain contains four transmembrane regions and is likely to possess
a sterol isomerase catalytic activity [1].

The profile we developed covers the entire EXPERA domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: March 2015 / First entry.

[ 1] Sanchez-Pulido L., Ponting C.P.
     "TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common
     metabolic disease."
     Front. Genet. 5:439-439(2014).
     PubMed=25566323; DOI=10.3389/fgene.2014.00439

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