{PDOC51756}
{PS51756; LXG}
{BEGIN}
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* LXG domain profile *
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The bacterial  LXG  domain contains a conserved [LF]-X-G sequence motif and is
predicted to assume an alpha-helical bundle fold. The LXG is predicted to be a
secretion signal  for  the  type  VII  secretion  system  of Mycobacterium and
Bacillus species. It is likely to utilize the ATP-dependent YueA pumps and the
potential peptide-binding  EsaC  domain  as  partners  for  extrusion from the
producing cell [1,2].

The profile we developed covers the entire LXG domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2015 / First entry.

[ 1] Zhang D., Iyer L.M., Aravind L.
     "A novel immunity system for bacterial nucleic acid degrading toxins
     and its recruitment in various eukaryotic and DNA viral systems."
     Nucleic Acids Res. 39:4532-4552(2011).
     PubMed=21306995; DOI=10.1093/nar/gkr036
[ 2] Holberger L.E., Garza-Sanchez F., Lamoureux J., Low D.A., Hayes C.S.
     "A novel family of toxin/antitoxin proteins in Bacillus species."
     FEBS Lett. 586:132-136(2012).
     PubMed=22200572; DOI=10.1016/j.febslet.2011.12.020

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