{PDOC51758}
{PS51758; LETM1_RBD}
{BEGIN}
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* Letm1 ribosome-binding (RBD) domain profile *
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Mitochondrial ribosomes   synthesize  core  subunits  of  the  inner  membrane
respiratory chain  complexes.  In  mitochondria, ribosomes are mainly membrane
associated and  translation  is  tightly  coupled  to  the inner mitochondrial
membrane. Mdm38/Letm1  is  a  conserved  membrane  receptor  for mitochondrial
ribosomes and specifically involved in respiratory chain biogenesis.

The Letm1  ribosome-binding  domain  (RBD)  is  necessary  and  sufficient for
interaction with  mitochondrial  ribosomes. It exhibits a predominantly alpha-
helical compact  fold  (see  <PDB:3SKQ>) and contains extended, highly charged
surface patches.  The  conserved  regions  most probably represent interaction
sites for  ribosomal  RNA  or  protein  subunits,  or for proteins involved in
mitochondrial protein biogenesis [1,2].

The profile we developed covers the entire Letm1 RBD domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2015 / First entry.

[ 1] Lupo D., Vollmer C., Deckers M., Mick D.U., Tews I., Sinning I.,
     Rehling P.
     "Mdm38 is a 14-3-3-like receptor and associates with the protein
     synthesis machinery at the inner mitochondrial membrane."
     Traffic 12:1457-1466(2011).
     PubMed=21718401; DOI=10.1111/j.1600-0854.2011.01239.x
[ 2] Bauerschmitt H., Mick D.U., Deckers M., Vollmer C., Funes S.,
     Kehrein K., Ott M., Rehling P., Herrmann J.M.
     "Ribosome-binding proteins Mdm38 and Mba1 display overlapping
     functions for regulation of mitochondrial translation."
     Mol. Biol. Cell 21:1937-1944(2010).
     PubMed=20427570; DOI=10.1091/mbc.E10-02-0101

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